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Re: Treatment Resistant Depression + Wellbutrin Add On

Posted by Christ_empowered on February 13, 2019, at 5:48:36

In reply to Treatment Resistant Depression + Wellbutrin Add On, posted by bonesintoronto on February 12, 2019, at 11:00:53

hi. ssri+wellbutrin is a fairly common strategy. I've had a couple of acquaintances who did well on Lexapro+wellbutrin...the only difference, I think, is that Prozac is generally regarded as more "activating" than lexapro.

lyrica...I dunno. Here in the US, it doesn't seem to be as popular for anxiety as it is elsewhere. Meanwhile, benzodiazepine prescribing has hit new highs (true story). But..sedatives, in general, carry some risk of cognitive problems related to treatment. benzodiazepines in some populations are associated with more accidents, falls, impaired cognitive performance. Even the sedating older antidepressants (tricyclics) are kind of frowned upon in some groups, for similar reasons.

but..."do what works," right? I will say that I take gabapentin, which is less potent than lyrica but I think chemically-related, is effective for anxiety, etc. with other stuff on board, but I kind of suspect clonazepam, lorazepam (high potency benzodiazepines) caused fewer concentration and memory problems, during treatment.

clonazepam can be great for agitation, anxiety....but over the long haul, it seems more likely than many other benzodiazepines to cause depression or make depression worse. way back when, I had some -severe- mood problems that were definitely at least partly due to long term, daily clonazepam treatment. im not trying to scare you, just saying...psychiatrists seem to be willfully blind to this "side effect." :-(

i dont know your medical coverage situation, but some people swear by modafanil. here in the US, its a controlled substance, but not as heavily controlled as traditional uppers. Ritalin is a traditional stimulant that is also used in depression now and then, especially when there are issues with other health problems, fatigue, concentration problems, lethargy, etc.

its still "off label," but some cns drugs are used in mood problems, such as mirapex. I think its fda-approved for dementia (?), but the appeal is that it can help lift mood by acting on dopamine...

but its not a traditional stimulant, so there's not a big problem with psychosis, euphoria, dosage escalation, agitation, etc.

-if- you and your prescriber decide to see about stopping the lyrica, please please please do yourself a favor and ask for a very, very slow taper. same with any benzodiazepines, especially the high(er) potency ones.

ok. hope this helps a bit.




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