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Re: MgVPA and q about combining buspirone, quetiapine

Posted by Christ_empowered on February 10, 2019, at 9:45:17

In reply to MgVPA and q about combining buspirone, quetiapine, posted by cadburyhesychasm on February 9, 2019, at 8:55:33

i dont like valproate, personally. we have different "issues," trileptal (oxcarbazepine) an option? dosages vary wildly, but based on my own experiences and what I've observed in others, I"d guess-timate that anywhere from 300mgs-1200mgs+ could "get the job done."

If I recall correctly, there's a depakote+seroquel interaction...have you and/or your prescriber(s) done a drug-drug interactions check?

Given the option, I think I'd go for seroquel over olanzapine. The metabolic effects aren't as terrible (group level) and there's a far wider dosage range, plus the TD is supposed to be less common w/ quetiapine, and I think EPS is less of an issue, too...which makes sense, given the quetiapine is a low potency neuroleptic.

-if- olanzapine is a treatment you'd like to pursue, could someone prescribe metformin with it? its a drug used in diabetes II, also used w/ "atypicals" to reduce weight gain and metabolic nastiness. also...Prozac, with the olanzapine? the olanzapine+fluoexetine combination is availble here, in the US, in fixed combinations as Symbyax. Although -any- antidepressant+'atypical' neuroleptic combination might prove helpful, the Symbyax combination has been extensively studied, so...there's that.

buspirone seems to help improve tolerability of neuroleptics, at least in some animal seems it somehow reduces the frequency and intensity of "vacuous chewing movements" (read: animal version of TD) from long term haloperidol treatment. it also can help under-performing antidepressants provide more mileage w/ anxiety, depression, ruminations. for that reason, the quetiapine+buspirone combination intuitively makes sense, because sufficient doses of quetiapine produce a reuptake inhibitor metabolite, which helps improve mood in some people, some times.

i am sorry you're suffering. are supplements available where you live? personally, I think anyone on psych drugs, especially the neuroleptics, should take antioxidants. natural form vitamin E+vitamin C, in particular, seem to help -me- tolerate my 'atypical' and I do not yet have TD, 10 years into full dose treatment.

OK. again, sorry about all this, and please do keep in mind that I"m just some poster on an internet forum...please, please make contact with a skilled prescriber and follow their treatment advice.




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