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Re: Promising depression drugs to watch for in 2019 Lamdage22

Posted by Hugh on January 11, 2019, at 11:15:56

In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on January 1, 2019, at 5:14:42

> This Sage-217 is a mystery to me. What is the mode of action? Does it work for anxiety? Is it ok when you are inclined towards psychosis? What are side effects and risks?

"Its mechanism of action is unknown, but it appears to be a positive allosteric modulator of GABA-A receptors with a binding site distinct from benzodiazepines."

The above quote is from the FDA Briefing Document for brexanolone, the intravenous form of SAGE-217.

https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/PsychopharmacologicDrugsAdvisoryCommittee/UCM624643.pdf


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poster:Hugh thread:1102565
URL: http://www.dr-bob.org/babble/20181024/msgs/1102738.html