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Combining Effexor n Atomoxetine; can it be done?

Posted by JohnBoy2000 on August 3, 2018, at 18:52:43

Basically - I tried combining it with high dose atomoxetine - low dose effexor - no tolerance for it.
Could it work with - high dose effexor - low dose atomoxetine?

So - I normally dose Strattera/Atomoxetine in the morning.

I wanted to add in a serotonergic component - so I tried Effexor.

It combined awfully dosed simultaneously with Atomoxetine in the morning - so I tried it at 4 pm - and it was better tolerated.
I can't dose it at night - as it induces insomnia like that.
I dosed it to a max of 75 mg - as that was all I could tolerate.

But ultimately - I had to taper off it as, although I benefited, the long term interaction proved to be negative.

So - Atomoxetine, I dose it high at 80 mg - activating - fantastic restoration of functionality.

I am considering reducing this dose, instead dosing Effexor in the morning to 225 mg - the activating dose - and using Atomoxetine as a "booster" of the noradrenergic effect, as it were.

I have no idea how that will work out.

Is it possible it may be tolerated given the dose increase/decrease, in contrast to the initially poorly tolerated approach?

As to the underlying pharmacology - technically Effexor has a favourable interaction profile but - it didn't work out that way before.

Can anyone lend some kind of insight as to this?




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