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Re: Benzos more rapid onst of action? beckett2

Posted by ed_uk2010 on June 21, 2018, at 17:20:28

In reply to Re: Benzos more rapid onst of action? ed_uk2010, posted by beckett2 on June 20, 2018, at 17:40:13

>Faster than sublingual alprazolam?

Should be similar.

Sublingual administration doesn't speed the onset of alprazolam, however, beyond a placebo effect. Sublingually administered alprazolam taken without water is absorbed more slowly than a plain alprazolam tablet swallowed whole with a glass of water. The reason is that alprazolam and other benzos are absorbed predominantly from the GI tract, not the mouth, and that a glass of water speeds absorption. A tablet swallowed on an empty stomach with a full glass of water will take effect most rapidly.

 

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