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Re: Any experience with Trintellix? linkadge

Posted by SLS on April 27, 2018, at 11:07:30

In reply to Re: Any experience with Trintellix? SLS, posted by linkadge on April 27, 2018, at 8:50:43

Hi Linkadge.

> Is parnate no longer working for you?

Parnate gives me a partial improvement that is inadequate for me to be able to get out of the house and become part of mainstream society. It gives me some mental energy and improves cognition and memory to a degree. Anhedonia persists, though. I am definitely better on it than off of it. However, a huge problem emerges when I take Parnate. Beyond what are already features of my baseline depression, Parnate causes a loss of interest and motivation to engage in activities. It is a sort of numbing feeling. It took me a little while to identify Parnate as the culprit. I tried tweaking the other drugs I take. It made no difference except that I relapsed upon lowering the dosage of any one of them. Then I remembered having this same problem whenever I would raise the dosage of Parnate to 60 mg/days. I was in my 20s.

I'll be okay.

My immediate plans are to switch from Parnate to Trintellix while leaving everything else in place. If this is a dead end, then I will switch from Trintellix to Effexor at a dosage of 300 mg/day or higher. My doctor is reluctant to have me on Trintellix and Effexor at the same time. Serotonin syndrome is a concern. I didn't think Trintellix was that potent as a serotonin reuptake inhibitor. I don't know. Trintellix does improve cognitive and memory function to a significant degree, even for people who do not have major depressive disorder. Since these things are among the most prominent symptoms for me, this is a welcome benefit. If neither Trintellix nor Effexor yield adequate results, it will be back to Nardil. I have not taken Nardil while on lithium and prazosin. I could probably live with a 50% improvement over baseline. I haven't had this since 1987.

I could use more alternatives. If you can think of anything for me, I could use some help. The only standard drugs I can think of that I have not tried are Luvox and Celexa. Of course, there might be combinations that I haven't tried yet.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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