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Re: pharmaceutical industry and their 'reinventions'.

Posted by Hordak on April 16, 2018, at 16:51:31

In reply to Re: pharmaceutical industry and their 'reinventions'. » Hordak, posted by SLS on April 14, 2018, at 0:41:12

> > > > How the f*ck is Vilazodone totally different?
> > > > It's an SSRI with some 5HT partial agonism...
>
> > > In what ways were you disappointed by vilazodone?
>
> > I am not disappointed in it, because I haven't tried it
>
> Would the world be a better place without vilazodone? I don't know.
>
> > but it's nothing "new".
>
> Perhaps it is new enough for some people.

#==> Yes, but there is a certain dogma among psychiatrists to push SSRIs on everybody... for different types of depression there are different fitting antidepressant-classes, but many doctors try the "one size fits all" route...

If someone suffers from psychomotor retardation, hypersomnia, weight gain, then Sertraline, Duloxetine or Bupropion might indeed be the fitting med. But pushing the same med on someone with converse symptoms might be fatal.

> I found vilazodone to be cleaner than any SSRI I tried. Unfortunately, my response to it was short-lived. Still, it "felt" different than Lexapro.
> What do you think of vortioxetine?

#==> From what I have read the 5ht1a agonism of Vortioxetine is awesome, for a few weeks. This receptor develops tolerance rapidly - more rapidly than other receptors. No stable way to achieve response here. Apparently it does all the wonderful things that MDMA does for empathy & pro social feeling (in a smaller proportion), but this effect will not last.

There are better more long lasting ways to achieve an anxiolytic effect. If it was practical to antagonize 5ht1a directly in a long lasting manner, that would be a great anxiolytic, but the drugs that work here develop tolerance VERY rapidly...


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poster:Hordak thread:1098091
URL: http://www.dr-bob.org/babble/20180331/msgs/1098177.html