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Re: What is a good Norepinephrine increaser?

Posted by SLS on March 4, 2018, at 1:07:59

In reply to Re: What is a good Norepinephrine increaser? linkadge, posted by ed_uk2010 on March 3, 2018, at 15:49:43

> Hi Link,
>
> >Wellbutrin is (I believe) a...
>
> That just about sums up the pharmacology of Wellbutrin! No one ever seemed quite sure what it does.

Yup.

Wellbutrin made me feel quite a bit worse - mostly dysphoric. On the other hand, nomifensine, a potent DNRI, made me feel better. Why?

Wellbutrin increases the levels of nitric oxide via enzyme inhibition. There is some evidence that this action might contribute to the drug's antidepressant actions. A long time ago, the position held by a few researchers was that, although the exact mechanisms were not obvious or well understood, Wellbutrin ultimately increased noradrenergic (NE) activity. The degree to which Wellbutrin acts as a DNRI is rather small. Some people regard its direct effects on catecholamines to be negligible and not contributory to its therapeutic effect. I guess this begs the question, exactly how would one know what is the amount of anything that can be neglected.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1097121
URL: http://www.dr-bob.org/babble/20180212/msgs/1097154.html