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Re: All ADs Better than Placebo for Major Depression

Posted by Tabitha on February 24, 2018, at 10:05:11

In reply to Re: All ADs Better than Placebo for Major Depression, posted by linkadge on February 23, 2018, at 15:49:06

The whole point of a review like this is to look at best evidence, which is outcomes of double-blind RCTs. Those results may not necessarily match personal anecdote or current clinical opinion.

I'd assume that a lot of the gap between efficacy ranking and clinical practice is due to differences in acceptability (tolerance of side-effects). The study provides separate rankings for efficacy and acceptability.

The article links to full text of the study, so if you think there are research flaws, you can look there and point them out.

To your point about age, I don't see how older studies are less valuable than newer, unless the newer data contradicts the older, right? It makes sense that an older, effective drug is more well-studied than a newer one, so you can probably draw firmer conclusions about efficacy.





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