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Re: Does Zyprexa reduce serotonin?

Posted by Christ_empowered on November 13, 2017, at 14:18:56

In reply to Does Zyprexa reduce serotonin?, posted by Farshad on November 13, 2017, at 14:12:25

hi. I'm -not- an expert, but I'll share my (very rudimentary) understanding of this.

OK. The antagonism @ serotonin receptors helps agitation, anxiety, and may explain why Zyprexa is easier to tolerate than higher doses of, say, Haldol.

the antagonism @ serotonin receptors may also explain why Zyprexa (and other "atypical" tranquilizers) can boost antidepressants, and help mood on its own, too. risperidone also acts as an antagonist at a number of serotonin receptors, and it has greater tolerability (up to about 6mgs, I think) than Haldol, plus a beneficial impact on mood, agitation, anxiety, etc. that often isn't seen with "conventional" tranquilizers.

its worth noting that buspirone has some overlap with "atypical" tranquilizers, and it has also been used to boost under-performing antidepressants, sometimes with good results.




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