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Re: NE strengths of Reboxetine vs Atomoxetine

Posted by SLS on October 16, 2017, at 18:56:39

In reply to Re: NE strengths of Reboxetine vs Atomoxetine linkadge, posted by MightyKondrian on October 16, 2017, at 16:15:45

Hi.

Heteroreceptors for a given neurotransmitter are located on the membranes of neurons that use another neurotransmitter for synaptic messaging. For instance, a dopaminergic neuron may have serotonin receptors (heteroreceptors) along its axon that serve to inhibit its firing (action potential propogation). In this way, serotonin can serve to inhibit or "calm" excessive dopamine or norepinephrine activity that may be occurring in fear or anxiety centers in the brain, including the amygdala. Serotonin 5-HT1a receptors often perform this function. Similarly, serotonin 5-HT1a heteroreceptors modulate activity in the prefrontal cortex (PFC) and hippocampus. More recently, it has been observed that 5-HT7 heteroreceptors exist that could be implicated in mood, anxiety, and OCD disorders. This elegant network of stimulatory and inhibitory interactions creates a dynamic that makes it impossible to understand the brain by thinking in terms of chemistry without considering its circuitry.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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URL: http://www.dr-bob.org/babble/20161215/msgs/1095464.html