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Re: NE strengths of Reboxetine vs Atomoxetine

Posted by linkadge on October 12, 2017, at 15:03:30

In reply to NE strengths of Reboxetine vs Atomoxetine, posted by JohnBoy2000 on October 12, 2017, at 4:20:51


According to Wikipedia,

Atomoxetine NET ki 5
Reboxetine NET ki 13.4

The problem with ki, is it connects the binding of the molecule to the concentration of the drug. The issue with this, is that taking 10mg of either drug, wouldn't necessarily result in the same drug concentration in the brain. The concentration is affected by rate of absorption, elimination half-life, brain penetrability etc.

My guess is that higher doses of atomoxetine are needed because it isn't as well absorbed as reboxetine, but I have no idea.





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