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Re: NE strengths of Reboxetine vs Atomoxetine JohnBoy2000

Posted by SLS on October 12, 2017, at 8:30:48

In reply to NE strengths of Reboxetine vs Atomoxetine, posted by JohnBoy2000 on October 12, 2017, at 4:20:51

If you are to remain focused on NE for depression, I recommend desipramine. It has been studied for decades. It also works for ADHD


- Scott


> Atomoxetine = 0.36 nM
>
> Reboxetine = 8.2 nM
>
> Perhaps there are more accurate IC50 values out there though.
>
> Atomoxetine is dosed up to 100 mg
> Reboxetine to 10 mg max.
>
> Reboxetine supposedly failed clinical trials as an AD, but was approved anyways.
>
> Atomoxetine supposedly failed clinical trails as an AD, but was approved for ADHD.
>
>
> For myself - I've only ever responded to NE enhancing drugs so, I'm just looking for the most powerful one in that capacity.
>
> According to them IC50 values - that would be atomoxetine, right?


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I dream of things that never were and ask why not.

- George Bernard Shaw

 

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