Psycho-Babble Medication | about biological treatments | Framed
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Re: Trintellix...Weaker SRI?

Posted by linkadge on October 8, 2017, at 15:15:54

In reply to Re: Trintellix...Weaker SRI?, posted by phidippus on October 8, 2017, at 14:36:36

Yeah, it's actually got a couple of mechanisms which make it interesting.

It is a 5-ht1a agonist and 5-ht1b agonist.
Both of these have antidepressant effects. 5-ht1b agonists probably have even more antidepressant and anti-OCD effects than 5-ht1a agonists (5-ht1a agonists being more effective for anxiety).

It is a 5-ht1d antagonist, which might offset some of the negative hormonal effects of the SSRI effect (i.e. grown hormone blunting).

It is a 5-ht3 antagonist, which might contribute to anti-anxiety effects, and offset SSRI nausea.

And, as SLS mentions, it is a 5-ht7 antagonist - which can have faster acting antidepressant effects (especially in changing depression associated sleep changes).




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