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Re: Are there any 5ht1a Inverse Agonists? Hello321

Posted by SLS on July 26, 2017, at 2:17:42

In reply to Are there any 5ht1a Inverse Agonists?, posted by Hello321 on July 25, 2017, at 23:17:34

> Been some time now ive been trying different meds hoping to find relief for some intense anhedonia. Lately ive gotten interested in the 5ht1a receptors effects on brain function/mood. And i had at one point tried buspar and it had a very strong, negative effect on my anhedonia from the first dose. And so now im thinking the opposite of an agonist/inverse agonist at the 1a receptors might be beneficial for me. Ive taken a few non selective 5ht1a antagonists with no benefit. But an antagonist isnt quite the opposite of an agonist like buspar. An inverse agonist would be needed to get the opposite effect. But are there any 5ht1a inverse agonists?

You might take a look at Trintellix. It is a full agonist at 5-HT1a receptors.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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