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Re: Any thoughts on JZP-110 (DNRI / NDA late 2017)

Posted by SLS on July 16, 2017, at 8:57:33

In reply to Any thoughts on JZP-110 (DNRI / NDA late 2017), posted by PeterMartin on July 15, 2017, at 21:18:42

Hi, Peter.

> Has anyone followed this drug or have info on it? Could it possibly be helpful for mood disorders or sleep issues caused by psych meds?
> Thanks for any discussion.

Thanks for discovering and sharing!

I'm sure you are aware that this drug is a reuptake inhibitor of both dopamine and norepinephrine. It reminds me of nomifensine (Merital) in this respect. Nomifensine was a good antidepressant. Lots of people found it to be the only medication to successfully treat their depression. Unfortunately, the drug was withdrawn from market by the drug company due to a few reports of hemolytic anemia. There was some debate as to whether this was really necessary. I tried nomifensine. I experienced a brief partial response to it.

If I weren't taking a MAOI (Parnate), I would consider this drug for myself. I might switch if it emerges as a great antidepressant.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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