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Re: Measuring Drugs Activity at Receptors

Posted by linkadge on July 2, 2016, at 8:41:05

In reply to Re: Measuring Drugs Activity at Receptors, posted by Hello321 on July 1, 2016, at 16:07:36

Yeah, lower Ki means higher receptor affinity for a particular concentration of the drug (i.e. more active at that receptor).

The best site for Ki is:

http://kidbdev.med.unc.edu/databases/pdsp.php

However, one must also consider the factors affecting concentration of the drug namely:

- dose level
- half life
- absorption
- metabolism

I.e. a drug with low absorbtion and / or high metabolism, would need a higher dose to achieve a certain concentration.

Linkadge



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