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Re: Trazodone in divided doses or all at bedtime?

Posted by SLS on July 2, 2016, at 6:49:39

In reply to Trazodone in divided doses or all at bedtime?, posted by Lamdage22 on July 2, 2016, at 5:57:27

> Hey ya'll,
>
> hope everything is okay. I take 75mg of Trazodone at night.
>
> Any advice?


The half-life of trazodone is approximately 12 hours, regardless of delivery system. I see that trazodone blood levels spike and drop-off quickly after a dose of the original IR version whereas the extended-release verson (Oleptro) produces a much smoother AUC (area under the curve). However, both preparations arrive at the same blood level after 12 hours. Because you are using trazodone for something other than a sleep-aid, I would either take the IR version three times a day on an empty stomach or one Oleptro at night. For the most part, I tend to dose in a way that produces the smoothest blood level AUC. There may be situations where you would want a blood-level spike. I just can't think of any right now.

Changing your dosing schedule is, of course, just an experiment. You might find that your current schedule of administration works best. I will be interested to see where you end up.

Good luck.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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