Posted by linkadge on July 1, 2016, at 13:54:29
In reply to Re: tardive dementia (?), posted by rjlockhart37 on June 30, 2016, at 22:23:10
There is some evidence that antipsychotics can lead to cortical thinning / brain atrophy. Studies done in monkeys given typical and atypical antipsychotics showed some evidence of this. I think there was a study suggesting that certain supplements (i.e. vitamin e, melatonin) could offset this to some extent.
I believe in taking the lowest dose possible, and experimenting with lower doses and / or alternatives. Of course, with severe illness, this should be done with supervision.
Dopamine and serotonin help regulate brain plasticity. Blocking neurotransmitter receptors for years on end might be expected to reduce this plasticity. Atypicals too, could increase the probability of glucose dysregulation in the brain, which could affect cognition.
If you need AAP's then you need them. However, if I had to take Zyprexa, I'd be asking myself. Can I get away with 10mg less by adding vitamin C / niacin, melatonin etc. Can I get away with less by exercising, dietary changes, quitting smoking, therapy, sleep hygiene etc?
Linkadge
poster:linkadge
thread:1090044
URL: http://www.dr-bob.org/babble/20160609/msgs/1090066.html