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Re: ALL OK

Posted by SLS on January 27, 2016, at 6:52:57

In reply to Re: ALL OK, posted by john locke on January 27, 2016, at 5:44:26

I would think that anything that increases acetylcholine (ACh) tone would cause depression rather than prevent it.

Acetylcholine cholinesterase inhibitors(physostigmine, donepezil, rivastigmeine, galantamine, etc), drugs that increase ACh levels, induce depression whereas ACh muscarinic receptor antagonists like scopolamine improve depression. This assumes that muscarinic receptors in areas involved in depression predominate over nicotinic ACh receptors, which some suggest can improve depression.

1. pro-ACh = depressive - enhanced cognition and memory
2. anti-ACh = antidepressive - impaired cognition and memory

These are simplistic generalizations. I'm sure things are more complicated than this. If the 'racitams improve depression, I'm not sure how they do it.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1085722
URL: http://www.dr-bob.org/babble/20151225/msgs/1085731.html