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Re: I'm stuck with anhedonia/numbness/apathy

Posted by SLS on November 10, 2015, at 16:41:38

In reply to Re: I'm stuck with anhedonia/numbness/apathy, posted by hello321 on November 10, 2015, at 11:45:09

> Cyproheptadine eventually stopped working for me as I slowly raised my dose of it over time, because it would regain effectiveness when I raised the dose.
>
> But yep, it worked amazingly for the anhedonia I experienced after adderall screwed me up.

Have you ever tried Remeron? If not, it might be worth your time to research it. It blocks two of the three 5-HT2 serotonin receptors that cyproheptadine does. Remeron is an antagonist at 5-HT2a and 5-HT2c *, while cyproheptadine adds 5-HT2b antagonism. Of course, Remeron also increases NE release and disinhibits serotonin neurons by blocking NE alpha-2 receptors. If you already tried using Remeron to help with your anhedonia without success, that might be an indicator that the 5-HT2b receptor was critical to your improvement with cyproheptadine. It would be interesting to know.

Unfortunately, a drug called ritanserin has been relegated to lab experiments, despite being a clean 5-HT2a/b/c and 5-HT7 receptor antagonist. By itself, it is not much of an antidepressant, but it has been suggested that it would make a good augmenter of antidepressants. It was once dubbed a great drug without an indication. Since the patent expired long ago, I doubt anyone would be interested in developing it for market.

Wikipedia entries:

Cyproheptadine binding profile:

https://en.wikipedia.org/wiki/Cyproheptadine#Pharmacology

Remeron binding profile:

https://en.wikipedia.org/wiki/Cyproheptadine#Pharmacology

Ritanserin binding profile:

https://en.wikipedia.org/wiki/Ritanserin#Pharmacology

* Remeron is actually an "inverse agonist" at 5-HT2c receptors according to Wiki. An inverse agonist is sort of like a super-antagonist. It pushes the state of the receptor/neuron in a direction opposite to that which the neurotransmitter or agonist would.

- Scott


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I dream of things that never were and ask why not.

- George Bernard Shaw

 

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