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Re: Switching from Sertaline to Luvox CR. Thoughts?? » Scleme1

Posted by SLS on September 14, 2015, at 23:00:10

In reply to Re: Switching from Sertaline to Luvox CR. Thoughts?? » SLS, posted by Scleme1 on September 14, 2015, at 20:22:22

> Scott - thanks for the response. I appreciate your input. I do hope that Phiddipus chimes in, as I would love to hear how he is doing on the Brintellix. I'll try to answer a few of your ?'s below.

> > I am a little surprised that Zoloft worked well for you with respect to OCD and anxiety.

> Quite honestly, I'm not even sure the meds are doing much for me anymore. I've only ever been on the 2 SSRI's - Paxil and Zoloft. I've been on them so long, I don't remember what it was like to be without them. It seems like they both have worked relatively well, but I feel like Paxil did work a little better for me. On the Zoloft, I feel like I get agitated a little easier, and of course - I'm having this terrible insomnia/agitation/akathisia side effect. I don't remember ever having anything like that while on the Paxil.

Zoloft = sigma-1 antagonist = pro-akathisia
Luvox = sigma-1 agonist = anti-akathisia

I think the chances of your having akathisia with Luvox are pretty small. We'll see, I guess.

> I think I'm going to give Luvox CR a try for a few weeks.

You really need to think in terms of months with OCD - not weeks. With SSRIs, there is a tendency to need higher dosages than those that are used for depression. It also takes more time to see a response emerge.

> My doctor is also willing to let me try clomipramine, so that's another option. She has had great success combining low dose clomipramine with several of the other SSRI's.

That's very interesting.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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