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Re: SSRI + Dexedrine, dangerous bc serotonin syndrome? tom2228

Posted by phidippus on May 23, 2015, at 18:42:06

In reply to Re: SSRI + Dexedrine, dangerous bc serotonin syndrome? phidippus, posted by tom2228 on May 21, 2015, at 13:29:04

>how SRIs like clompiramine and imipramine cannot be combined with an MAOIs without producing SS while other TCAs with SRI properties, including amitriptyline can?

Do clomipramine and imipramine always produce SS when combined with MAOIs?

Is the MAOI test global and suitable for other kinds of medicines that modulate serotonin?

How often has amytryptaline been observed not to to cause SS with MAOIs

>it remains uncertain if amitriptyline is significantly serotonergic

And the way to test if it is serotogenic is to couple it with an MAOI? No, I think not.

>Weakly serotonergic drugs such as l-tryptophan precipitate typical, dose-dependent, but mild, ST symptoms when combined with MAOIs (Oates and Sjoerdsma, 1960). This indicates that even small elevations of serotonin, added to the effects of an MAOI, are sufficient to precipitate clinical features of ST (for a detailed exposition of this argument see Gillman, 2006a).
>Amitriptyline does not produce ST when added to an MAOI (Gillman, 1998). It may thus be inferred that amitriptyline does not significantly raise serotonin levels in humans.

I don't know what I think of the inference. Something else could be going on. There are better ways to determine if amy is serotogenic.

>ious explanation for this crucial difference. Further PET-derived SERT-binding studies, comparing all the TCAs directly under similar conditions, may further elucidate this important issue."

I agree.





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