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Re: SSRI + Dexedrine, dangerous bc serotonin syndrome?

Posted by tom2228 on May 6, 2015, at 9:29:32

In reply to Re: SSRI + Dexedrine, dangerous bc serotonin syndrome?, posted by kilo8 on May 5, 2015, at 22:54:24

> Hello,
> I have been trying NAC 600mg but I dont think it helps me. NAC actually raises glutamate this means if you have too much glutamate already it might even make it worse.
> How much seroquel do you take?
> And what exactly are your issues?
> Mine are depression,gad,ocd. I read that seroquel can be used as sleeping pill at a very low dose. But in general I'm scared of APs cause of the possible side effects. I'd also be scared of abilify cause of the risk of dyskinesia.
> @ tom
> Wow, that is a hell of a combo! I mean desoxyn is methamphetamine right? Mixing this with a MAOI and a TCA sounds really risky to me. I mean is your doc totally experienced? I think most pdocs wouldn't even want to prescribe a MAOI without adding anything.
> Does this combo at least help you? I mean when you go on such a combo does this mean that you are treatment resistant and nothing else worked before?
Yeah Desoxyn is methamphetamine hydrochloride. It's more of a mellow medication than the dextroamphetamine I take now and can be quite effective for ADHD if you can motivate yourself to be productive, which is one of the reasons I'm on Vyvanse now instead -- I need all the drive I can get (but not as much as Adderall) at this point in my life.

I was on the Desoxyn and Marplan for about 5 years and while it worked for some time, looking back I was still struggling, very much so last year, which is when I got on tricyclics as well, nortriptyline now desipramine. Once I got up to the dose I'm on now (125mg) my depression, motivation, and anxiety really started to improve. It also helps with my ADHD and cravings/ desire to use meth (I'm a recovering addict).

I still struggle with some depression here and there but since the desipramine and adding olanzapine and T3 (triiodothyronine) things are vastly improved. Since January I've gone from 5 years' unemployment, having dropped out of school, and shooting up street meth daily to a good job that I really like, being able to pay my rent and support myself for the first time in my life, and finally making friends.

I honestly struggle with hypomania the most these days. I know the desipramine plays a central role in that, but I need it at the dose it's at. Low-dose Depakote was just added to the lithium and low doses of olanzapine, Abilify, and Lamictal that I already take. It seems to be helping.

I'm on a lott of meds and the combination makes a lot of doctors shriek, but if it's done right the risk is overdramaticized. I've never had any sort of safety issue and my blood pressure has recently fallen since adding back the dextroamphetamine. The drama tends to lend itself to lack of experience among the majority of psychiatrists. It's been really hard to find a willing doctor since moving to the West Coast, but the one I just started seeing didn't even flinch. She said "Well it's highly inconventional, but everyone's different." And that was the end of it.

By the way, Seroquel (along with clozapine) has the lowest risk of EPS among the atypical antipsychotics. Zyprexa has pretty low rates of EPS too, which I'm on, and is a great add-on in low doses for depression and anxiety. Good luck




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