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Re: MAOIs, hypotension, mental and muscular weakness

Posted by FredPotter on April 6, 2015, at 18:14:00

In reply to Re: MAOIs, hypotension, mental and muscular weakness » Robert_Burton_1621, posted by ed_uk2010 on March 22, 2015, at 16:55:15

I've taken Nardil 45mg twice a day for about 8 years. Thanks for the discussion on weakness everybody. I thought it was Chronic Fatigue Syndrome (CFS), particularly as I also have Fibromyalgia (FM) like symptoms. I've actually been diagnosed with CFS/FM by exclusion, by a neurologist. Well, I don't think he excluded enough. I think the "FM" is statin damage and now, thanks to all you good people's observations, the fatigue and weakness is probably explained by hypotension side effects of Nardil. I remember 4 years ago, just before I gave up drinking, I would usually drink a bottle of red wine between 6pm and 11pm. Such pathetically slow imbibition left me feeling sober at bed time. However I would wake up to go to the toilet in the night but I would be unable to stand. After a week or so I couldn't even crawl or kneel to use the toilet. This resulted in unsavoury accidents. By morning I was stronger but was sleepy and had poor concentration. This led to me losing my job (aged nearly 65). I said to my Dr that alcohol couldn't do this surely, but he nodded sagely.

So was this a tyramine effect from the red wine or just the interaction of booze and Nardil? I did avoid chianti, sadly. Since then I've noticed a much milder reaction with the milder drugs cannabis (which I don't like anyway) and even kava kava. I've also noticed that I sometimes stand with bent knees and I start shuddering all over. Fun. A neuropharmacologist recommended I supplement it with 50mg of nortriptyline at night, it being in effect a norepinephrine re-uptake inhibitor (not all TCAs are contra-indicated but some do have serotonergic properties that can lead to Serotonin Toxicity (ST) which can be fatal; it's very important to get this right; imipramine and clomipramine are definitely not safe, but there may be others).

I still have lowish BP but that's good I think. The body does seem to acclimatise, well mine does, but it can take a long time, in my case


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