Posted by ed_uk2010 on January 17, 2015, at 15:56:23
In reply to Re: Splitting pills. Reliable or not? (@Ed and others) » ed_uk2010, posted by europerep on January 17, 2015, at 15:15:08
Hi!
>yes, your reply helps me a lot...
Oh good.
>I'm sure at least some patients out there would benefit from an availability of a wider dose range for these drugs...
They probably would, yes. Such issues tend not to get explored a great deal because doctors prefer to think of drugs as having an effective dose range which is similar for most patients - this makes medicine easier. Such doses are usually derived from clinical trials and therefore give the prescriber an idea of what dose is likely to be suitable for most patients. This does not, of course, account for individual differences in drug metabolism, elimination and clinical response. Individual differences are much greater for some drugs than others. In general, differences in dosage requirements are most pronounced for drugs with a narrow therapeutic index (ie. a small difference between the effective and toxic blood level) where there are also large differences in metabolism and elimination between patients. Drugs such as TCAs, which rely a lot on the liver enzyme CYP2D6 for metabolism, require a particularly individual titration partly due to large differences in CYP2D6 enzyme activity - which is controlled by inherited genetic factors (but interacting drugs are also frequently relevant). On the other hand, due to differences in the way various people's brains respond to the drug, it's hard to correlate the drug level to the response.
>It happens to be a UK product, so if you want I can tell you the manufacturer's name, and you could verify that.
Sure, what is it? I'm not aware of that many different products. There's King pharma (which are film coated), NRIM pharma (not film coated) and a blister packed import called Paxtibi. I suspect your tablets are made by NRIM. Correct?
Germany, Italy, the Netherlands and Spain have accepted the NRIM product license based on the mutual recognition procedure - in this case with the UK acting as the reference member state.
poster:ed_uk2010
thread:1075154
URL: http://www.dr-bob.org/babble/20150102/msgs/1075197.html