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Re: Tianeptine or Amisulpride + Selegiline » notredame1909

Posted by SLS on January 17, 2015, at 8:05:40

In reply to Tianeptine or Amisulpride + Selegiline, posted by notredame1909 on January 16, 2015, at 4:12:50

> Hi,
>
> I'm diagnosed with anxiety disorder.
>
> I'm currently taking Tianeptine 3 tabs 3 times a day. It helps me a lot (standard dosage 1-1-1 doesn't work), but didn't take all the anxiety off.
>
> Another drug which helped me a lot was Amisulpride - 50 mg once daily.
>
> Tianeptine (in higher dosages) and Amisulpride (in lower dosage)increase dopamine. And I think increasing dopamine helps my anxiety.
>
> So I would like to add selegiline - 5-10 mg in the morning.
>
> 1. Can I take it with tianeptine? I know MAOI shouldn't be mixed with SSRI's and TCA'a, but tianeptine is SSRE (selective serotonin reuptake enhancer) and selegiline up to 10mg is MAO-B inhibitor (it only acts on dopamine).
> So I would like to take tinaptine 3 tabs 3 times a day, and selegiline 1 tablet (5 or 10 mg) a day.
>
> 2. If I cannot take selegiline with tianeptine, then I would like to take amisulpride 1 tab 50 mg a day, and selegiline 1 tab (5 or 10 mg) a day.
>
> What do you think?
>
> Thank you.

I would be hesitant to combine tianeptine with a MAOI unless you know a doctor who has experience with this. Despite tianeptine being described as being the "opposite" of a SSRI, I don't know what its secondary effects on serotonin pathways are. I did find this, though:

http://www.ncbi.nlm.nih.gov/pubmed/23048001

Amisulpride should be okay.

Regarding TCAs, you can mix MAOIs with desipramine or nortriptyline. I am currently taking Parnate with nortriptyline.


- Scott


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I dream of things that never were and ask why not.

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