Posted by linkadge on January 9, 2015, at 20:39:49
http://www.medicalnewstoday.com/releases/287733.php
The study seems to suggest that sigma-1 agonists can prevent the NMDA hypofunction that occurs with cb-1 agonism.
In other words, in cases where there is excessive cannabinoid signalling (causing glutamate hypofunction) sigma-1 agonism can reverse / offset this.
This possibly explains some of the effect of fluvoxamine on psychotic depression.
Linkadge
poster:linkadge
thread:1075014
URL: http://www.dr-bob.org/babble/20150102/msgs/1075014.html