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Sigma-1 Cannabinoid Interaction - Study

Posted by linkadge on January 9, 2015, at 20:39:49

http://www.medicalnewstoday.com/releases/287733.php

The study seems to suggest that sigma-1 agonists can prevent the NMDA hypofunction that occurs with cb-1 agonism.

In other words, in cases where there is excessive cannabinoid signalling (causing glutamate hypofunction) sigma-1 agonism can reverse / offset this.

This possibly explains some of the effect of fluvoxamine on psychotic depression.

Linkadge


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poster:linkadge thread:1075014
URL: http://www.dr-bob.org/babble/20150102/msgs/1075014.html