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Re: Nardil (Phenelzine) - Super high dose? » Uncouth

Posted by SLS on January 8, 2015, at 5:47:48

In reply to Nardil (Phenelzine) - Super high dose?, posted by Uncouth on January 7, 2015, at 19:38:20

My feeling is that you will not benefit from any further dosage increases.

It seems to me that you are "chasing" after a drug response with Nardil. Nardil is teasing you. I doubt that any one dosage is going to stick. This has happened to me and quite a few other people. Of course, if there were no safety concerns or intolerable side effects, you could keep going higher. However, this is not the case. Overdose can be fatal.

Nardil inhibits its own metabolism, so its kinetics are exponential rather than linear. Each 15 mg/day increase produces an accelerating drug effect. In the case of overdose, symptoms don't occur immediately, so one is tempted to take more. By the time overdose symptoms appear, it is often too late to simply stop taking it and wait it out. Drug levels end up going way too high, and it takes a long time for them to recede. If you begin to experience altered mental status (confusion or incoherence), you need to be taken to a hospital quickly. Driving yourself is not an option.

http://www.healthyplace.com/other-info/psychiatric-medications/phenelzine-full-prescribing-information/#overdose

Based upon my own experience with Nardil, I would be reluctant to go above 120 mg/day. However, I would hate to be responsible for your missing an opportunity to respond to treatment. Before increasing the dosage further, you might opt to get a blood test for MAO inhibition percentage, if they still exist.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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