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Re: Is clozapine induced agranulocytosis reversible? » Lamdage22

Posted by SLS on August 30, 2014, at 8:06:04

In reply to Re: Is clozapine induced agranulocytosis reversible?, posted by Lamdage22 on August 30, 2014, at 0:53:11

> From what i have read and heard, Seroquel has the best side effect profile if you take away weight gain by using Metformin!

What about Saphris (asenapine)? I have seen it work to produce antipsychotic and antidepressant effects. It may be particularly well-suited to treat paranoia. You could add it to your ongoing Seroquel treatment, just in case it doesn't confer sufficient antipsychotic activity. If you feel good, then you can try discontinuing the Seroquel. I don't think Saphris causes as much weight gain as Seroquel. Seroquel does have the potential to produce diabetes, but probably not to the same degree as clozapine. Latuda (lurasidone) is an antipsychotic that is not supposed to cause weight gain. I am guessing that there would be a reduced risk of diabetes. Very few people have tried it yet, and I really don't know how effective it is as an antipsychotic. However, it does have antidepressant effects. It produces NE alpha-2 antagonism (similar to Remeron (mirtazapine)), as well as 5-HT7 antagonism (similar to Brintellix (vortioxetine)).


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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