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Re: Buprenorphine(suboxone) for anxiety, depression...

Posted by Englishman006! on July 28, 2014, at 5:55:48

In reply to Re: Buprenorphine(suboxone) for anxiety, depression..., posted by rose45 on July 20, 2014, at 16:47:33

Buprenorphine is a semi-synthetic, mixed agonistantagonist opioid receptor modulator.

Investigational uses
A clinical trial conducted at Harvard Medical School in the mid-1990s demonstrated that a majority of unipolar non-psychotic persons with major depression refractory to conventional antidepressants and electroconvulsive therapy could be successfully treated with buprenorphine.[20][21][22][23][24][25][26] Clinical depression is currently not an approved indication for the use of any opioid, but some doctors are realizing its potential as an antidepressant in cases where the person cannot tolerate or is resistant to conventional antidepressants.

ALKS-5461, a combination product of buprenorphine and samidorphan (a selective μ-opioid receptor antagonist), is currently undergoing phase III clinical trials in the United States for augmentation of antidepressant therapy for treatment-resistant depression.[27]

Source - Wikipedia




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