Posted by linkadge on July 25, 2014, at 18:20:13
Apparently, agents which antagonist 5-ht7 receptors can act as antidepressants (and augmentation to other antidepressants).
Doing a little reseach, oleic acid (and oleamide) (readily present in olive oil) can act as a 5-ht7 antagonist (or modulator).
"saturation binding experiments, oleamide caused a 3-fold decrease in the affinity of [3H]5-HT for the 5-HT7 receptor, without affecting the number of binding sites. A Schild analysis showed that the induced shift in affinity of [3H]5-HT reached a plateau, unlike that of a competitive inhibitor, illustrating the allosteric nature of the interaction between oleamide and the 5-HT7 receptor. Oleic acid, the product of oleamide hydrolysis, had a similar effect on [3H]5-HT binding,"