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5-ht7 antagonists

Posted by linkadge on July 25, 2014, at 18:20:13

Apparently, agents which antagonist 5-ht7 receptors can act as antidepressants (and augmentation to other antidepressants).

Doing a little reseach, oleic acid (and oleamide) (readily present in olive oil) can act as a 5-ht7 antagonist (or modulator).

http://www.researchgate.net/publication/12730496_Allosteric_regulation_by_oleamide_of_the_binding_properties_of_5-hydroxytryptamine7_receptors

"saturation binding experiments, oleamide caused a 3-fold decrease in the affinity of [3H]5-HT for the 5-HT7 receptor, without affecting the number of binding sites. A Schild analysis showed that the induced shift in affinity of [3H]5-HT reached a plateau, unlike that of a competitive inhibitor, illustrating the allosteric nature of the interaction between oleamide and the 5-HT7 receptor. Oleic acid, the product of oleamide hydrolysis, had a similar effect on [3H]5-HT binding,"

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poster:linkadge thread:1068784
URL: http://www.dr-bob.org/babble/20140717/msgs/1068784.html