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Re: Latuda did not work out! Back to Zyprexa. » Danielj

Posted by stan_the_man70 on June 10, 2014, at 23:52:30

In reply to Latuda did not work out! Back to Zyprexa., posted by Danielj on June 10, 2014, at 17:00:24

http://thelastpsychiatrist.com/2010/10/zyprexa_and_fat.html#comment-12528

October 29, 2010 12:19 AM | Posted, in reply to Jack Coupal's comment, by Anonymous: | Reply

1) pharmacology does not exclude physiology, merely informs it.
2) Of course not. However, we know this:

Humans on zyprexa get hyperglycemia.
Rats on zyperxa get hyperglycemia.
Humans on zyprexa have a change in metabolism, which is causing hyperglycemia.
Rats on zyprexa have their mitochondria switch so that they prioritize fat oxidation, which results in hyperglycemia and hyperinsulinemia as a secondary effect.
In humans not on zyprexa, but with genetic tendency to aquire T2DM/ hyperglycemia, it is noted they have genetic traits which make their mitochondria prioritize burning fat for fuel first, which then makes them more insulin resistant. So, it is known that this zyprexa induced metabolic change does occur in humans under other circumstances (genetically), which makes them at risk to develop T2dm.

Considering the above, it is simple deduction to say that as of now it is a good hypothesis that human hyperglycemia post zyprexa is related to a switch to a primary fat burning state resulting in secondary glucose intolerance, hyperglycemia, and hyperinsulinemia, which results in diabetes and obesity (from hyperinsulinemia/increased appetite). It is not yet PROVEN but it is a reasonable hypothesis at this point in time.

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