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Re: Brexpiprazole-Here it comes

Posted by jrbecker76 on April 2, 2014, at 12:56:21

In reply to Re: Brexpiprazole-Here it comes BrainDamage, posted by SLS on March 29, 2014, at 6:58:04

> > > Cariprazine is a similar drug that I believe might be better for depression. It is like adding 5-HT7 antagonism to Abilify with emphasis on the D3 reward system.
> > Don't Overestimate me Scott! ;)
> >
> > If there were Pharmacologist grades on this Sight I would be "Dabbler" & You & Ed among Others would be "Professional-Amateur"
> I know less about psychiatry than what people assume I do. I just use big words. Fortunately, there are people with true knowledge and expertise posting on Psycho-Babble. I try to learn from everyone.
> > To be honest its probably another useless "Me-Too" drug
> I don't mind taking a "me too" drug if it were to mean that I could then be included in the "me too" club of treatment responders. It might be that a subtle difference in drugs will convert a TRD into a treatment success. For every new drug that becomes available, a certain percentage of previously treatment-resistant individuals will respond to it.
> I wish us both luck!
> - Scott

From a receptor affinity standpoint, Brex as the metabolite of Abilify is in itself less of a D2 partial agonist and more of a direct antagonist. From this logic, I would suspect that it's not necessarily an improvement in terms of providing a better antidepressant effect over Abilify itself.




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