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Re: TCAs calming vs. sedating/ nortrip vs. Saphris SLS » tom2228

Posted by phidippus on March 17, 2014, at 21:56:58

In reply to TCAs calming vs. sedating/ nortrip vs. Saphris SLS, posted by tom2228 on March 17, 2014, at 19:24:38

> I was thinking of desipramine because of its least side effects in general

It has the same anticholergenic side effects the rest of the TCAs have.

> My depression is severe and I'm nervous that if she won't go for the combo that the TCA alone won't be enough

Desipramine alone will not be anywhere near as effective as Marplan. Your best bet would be to add the drug.

, so I was wondering about nortriptyline.

It is a straight up NRI (norepenephrine reuptake inhibitor) and unlike Desipramine has little or no effect on serotonin.

> That being said, is the nortripyline sedation more calming, or is it more of the heavy, tiring, sleepy, mind-blocking type?

It was more calming for me.

Is nortrip, desipramine, or protrip good for anergic bipolar depression?

yes

>am thinking of asking to decrease or switch to Invega as it's said to be the least sedating AAP.

I had trouble sleeping on Invega. It is very energizing in some ways.

>how does nortrip's compare to Saprhis in this respect.

I would say Saphris is a lot more sedating than Nortryptaline

My recommendation is to request to add Nortryptaline to your Marplan and switch to Invega, but be aware you may lose some antidepressant benefits when you go off the Abilify. Maybe Latuda would be a better switch.

Eric


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