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Re: still feeling bad on Riluzole » SLS

Posted by g_g_g_unit on October 4, 2013, at 8:01:11

In reply to Re: still feeling bad on Riluzole » g_g_g_unit, posted by SLS on October 4, 2013, at 6:22:56

>
> For me, it seems that a combination of Minocycline + Lamictal has modulated excessive glutamate activity. I also take Abilify.

My Minocycline trial was cut short by Riluzole, but I still have a box lying around. I'm not that impressed by the results in OCD, though.

>
> I was very disappointed by riluzole. It didn't help at all. However, one cannot deduce from this that glutamate dysfunction is not contributing to depression and anxiety.

I know, it's pretty heartbreaking, especially since the data for anxiety/depression seems so promising.
>
> Have you ever tried Navane (thiothixine) or Phenergan (promethazine) for your anxiety?

To be honest, I get akathisia on tiny doses of AAP, so am not foaming at the mouth to try an older antipsychotic. I can't imagine the subjective effects would be too pleasant either.
>
> Prazosin is an interesting choice. Recent studies use 20 - 30 mg/day in divided doses. Despite the use of these higher dosages, one must nonetheless begin treatment using a single 1.0 mg dose given at night and follow up 2.0 - 3.0 mg. Even at this low dosage, temporary dizziness often occurs, so a gradual titration is recommended.
>
My GP vetoed the Prazosin idea because of low BP.

> Is there any history of trauma?
>

Not officially, though the last 5 years of living with an anxiety disorder could be described as traumatic.

I read that you said Prazosin could provide AD benefits in patients with childhood abuse .. my mother is narcissistic and a lot of hurtful recollections surfaced in therapy, though I've never been diagnosed with an official traumatic complex.

 

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