Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: ECT In Kids, Safe,Effective But Under utilizied » europerep

Posted by SLS on July 4, 2013, at 10:29:55

In reply to Re: ECT In Kids, Safe,Effective But Under utilizied » SLS, posted by europerep on July 4, 2013, at 6:55:52

> I think that the question of getting the right dose of ketamine is mostly, if not entirely, related to the psychedelic effects it produces at high(er) doses. After all, the pretty much universally used dosage of 0.5mg/kg, administered over 40 min. via IV infusion, has, at least as far as I know, not been "developed" or elaborated in any kind of way. It's just the dosage the first guys who studied ketamine in TRD came up with, and they sticked with it because it worked. It would be quite a coincidence if they had just accidentally found a "narrow therapeutic window."

You may be right. Perhaps I am mistaken in my recollection. Nevertheless, NMDA receptor partial agonism seems to be a more desirable mode of modulating glutamatergic neural activity than ketamine is. The risk of triggering psychosis is much reduced and oral agents now exist. The therapeutic indexes (safety / toxicity) of these drugs is quite a bit wider than that of ketamine.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1046274
URL: http://www.dr-bob.org/babble/20130617/msgs/1046424.html