Posted by Lou Pilder on May 27, 2013, at 15:28:47
In reply to Online automatic drug interaction checkers » Lou Pilder, posted by ed_uk2010 on May 27, 2013, at 13:17:06
> >Here is a link from drugs.com showing the interactions between Trileptal and Effexor.
>
> Unfortunately, this interaction checker is not accurate. There are no reports in the medical literature of venlafaxine + oxcarbazepine causing respiratory depression. These particular meds are not respiratory depressants, either alone or together.
>
> Beware of using the drugs.com interaction checker. Instead, use a reliable source such as the textbook 'Stockley's Drug Interactions', which is written by experts and uses a huge range of case reports and studies from the published medical literature.
>
> ed,
When no interaction is listed, that does not mean that there can not be an interaction.
In the case here, Trileptal is an anticonvulsant and has sedation listed as a consequence of taking the drug. Effexor has sedation also listed.
Drugs that sedate depress the central nervous system. These two drugs are CNS depressants. Reactions that are exponential rather than arithmetic can happen when more than one CNS depressant is taken. The danger is sudden death via cardiac or respiratory depression.
The drugs.com site even states that they do not have reports of events from combining the drugs, but they state that CNS depression can happen when the two drugs are combined. It may be that prescribers know that combining CNS depressants could cause death and do not prescribe them together. Another thought here is that Trileptal is a chemical modification of another anticonvulsant.
DRugs.com said what it said and I accept that the two drugs are CNS depressants. I have never seen the drugs profiled stating that they do not cause sedation, which is a characteristic of a depressant. I have also studied the chemical composition of the drugs and sedation can come from those chemicals.
Lou
poster:Lou Pilder
thread:1044214
URL: http://www.dr-bob.org/babble/20130527/msgs/1044361.html