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Re: Anything comparable to Nardil out there? » Tomatheus

Posted by Bob on April 30, 2013, at 12:55:43

In reply to Re: Anything comparable to Nardil out there?, posted by Tomatheus on April 28, 2013, at 15:07:08

> Topdog,
>
> I never experienced pronounced benefits lasting for more than three days with any psychiatric medication or medication combo other than the Nardil/doxylamine combo that I took from late 2005 through 2006, but I at least suspect that the condition that I've been trying to treat is idiopathic hypersomnia, and not clinical depression. The treatment of my hypersomnia and related symptoms is also more complicated now than it was back in 2006 because I now (since February 2007) have the symptoms of schizoaffective disorder to contend with.
>
> I think that if you're looking for a treatment that compares to Nardil that you'd want to look at Marplan, Parnate, selegiline, Rhodiola rosea, and possibly moclobemide, if that's available to you. All of the substances that I mentioned have been shown to be MAOIs of one type or another. It's my understanding that Marplan and possibly Parnate are both "irreversible" MAOIs (meaning that they remain bound to MAO for the lives of the enzymes), and like Nardil, both Marplan and Parnate inhibit both MAO-A and MAO-B. Selegiline (like Nardil, Marplan, and possibly Parnate) inhibits MAO irreversibly, but if my understanding is correct, it's preferential in its inhibition of MAO-B, especially at lower doses. Moclobemide is a reversible inhibitor of MAO-A, and Van Diermen et al. (2009) found that Rhodiola rosea inhibits both type A and type B MAO. My guess would be that Rhodiola rosea is reversible in its inhibition of the MAO enzymes since dietary restrictions are not required when taking it, but I don't know with 100 percent certainty that that's the case.
>
> It's my understanding that MAOIs come with more interactions than most psychiatric medications, but there are some medications that can be used to augment MAOI medications.
>
> Tomatheus
>
> ==
>
> REFERENCE
>
> Van Diermen, D., Marston, A., Bravo, J., Reist, M., Carrupt, P.A., & Hostettmann, K. (2009). Monoamine oxidase inhibition by Rhodiola rosea l. roots. Journal of Ethnopharmacology, 122, 397-401. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19168123
>


Hey Tomatheus,

Why did you only take the Nardil/Doxylamine combo for one year if it worked so well? Did the Doxylamine have a problematic side effect profile for you?

Bob

 

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