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Re: Buspirone.... cumulative effectiveness.... HELP!!! schleprock

Posted by SLS on March 26, 2013, at 23:43:54

In reply to Buspirone.... cumulative effectiveness.... HELP!!!, posted by schleprock on March 26, 2013, at 21:55:55

Buspirone has a metabolite known as 1-PP (1-pyrimidinylpiperazine). 1-PP acts like Remeron in that it raises norepinephrine levels via NE alpha-2 autoreceptor antagonism early in treatment. Perhaps 1-PP is interacting with the nortriptyline to produce overactivity of certain noradrenergic pathways in you. There is some suggestion that NE levels stabilize with continued exposure to 1-PP, but very little work has been done to study this.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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