Psycho-Babble Medication | about biological treatments | Framed
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Re: Effexor + Mirtazapine MORE effective than PARNATE!

Posted by linkadge on March 13, 2013, at 13:41:41

In reply to Re: Effexor + Mirtazapine MORE effective than PARNATE!, posted by vanvog on March 13, 2013, at 12:00:18

I think remeron acts more on norepinephrine release than serotonin release.

Its effects on norepinephrine are due to blocking the presynaptic noradrenergic alpha-2 receptors. This promotes norepinephrine release.

I think the serotonin action comes mainly from receptor blockade (5-ht2a/c,5-ht3) which increases the availability at 5-ht1a receptors.

Blocking serotonin 5-ht2a/c receptors also increases catecholamine release in certain brain regions, which might augment the NRI effects of effexor.

Also, remeron can improve sleep, and melatonin release, which might improve receptor sensitivites.





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