Posted by linkadge on March 13, 2013, at 13:41:41
In reply to Re: Effexor + Mirtazapine MORE effective than PARNATE!, posted by vanvog on March 13, 2013, at 12:00:18
I think remeron acts more on norepinephrine release than serotonin release.
Its effects on norepinephrine are due to blocking the presynaptic noradrenergic alpha-2 receptors. This promotes norepinephrine release.
I think the serotonin action comes mainly from receptor blockade (5-ht2a/c,5-ht3) which increases the availability at 5-ht1a receptors.
Blocking serotonin 5-ht2a/c receptors also increases catecholamine release in certain brain regions, which might augment the NRI effects of effexor.
Also, remeron can improve sleep, and melatonin release, which might improve receptor sensitivites.
Linkadge
poster:linkadge
thread:1040126
URL: http://www.dr-bob.org/babble/20130308/msgs/1040218.html