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Re: Ketamine and side effects jrbecker76

Posted by SLS on February 19, 2013, at 13:18:01

In reply to Re: Ketamine and side effects jrbecker76, posted by jrbecker76 on February 19, 2013, at 12:10:05

Perhaps you would do better with tianeptine. I don't know. You might not be a SSRI responder.

How did you react to Zoloft?

What about MAOIs?

I am seriously considering using deep TMS as a treatment to accelerate my response to medication. I don't think ketamine represents much more than an intriguing and potentially important heuristic observation, much as sleep deprivation is. It can produce a dramatic antidepressant effect transiently, but what do you do with it? If ketamine were observed to work synergistically with other drugs to make them work better and longer, I would agree that it has a clinical application. Do you know of any studies like that?

From what I have seen, there is a narrow therapeutic window for ketamine administration. One must be brought to the point of delirium without becoming unconscious. This can only be accomplished with the precision offered by infusions. Ketamine does not produce an antidepressant effect when used at dosages that are too high or too low. Injections just don't accomplish this as well as infusions do. I'm looking forward to the development of an oral agent by Naurex that acts as a partial agonist at the glycine binding site of the NMDA receptor / channel. It should have a wider therapeutic window and avoid psychotomimetic side effects. In the meantime, I am hoping that my impressions of ketamine are wrong, and that it does have practical applications to treat depression. I just haven't seen it yet.

Do you think that adding magnesium to ketamine would be helpful? What about memantine?

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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