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Re: Switch from Effexor to Pristiq

Posted by SLS on January 17, 2013, at 23:10:24

In reply to Switch from Effexor to Pristiq, posted by In_denial on January 17, 2013, at 18:41:26

> I would have posted this update on my thread from last month,but another babble user hijacked the thread.
>
> I've seen many posts around the web saying that Effexor and Pristiq are chemically the same. Maybe they are, but they metabolize differently. I was a long time Effexor user. I've switched from 150mg Effexor to Pristiq 100 and the results have been amazing. I only had mild symptoms for a few days after cuttingi the Effexor cold turkey. Much more uplifting! I think ithe fact that Pristiq works more on noradrenalin than Effexor is what I needed. When I previously tried higher doses of Effexor, I got extreme dry mouth and trouble sleeping. Not so with the Pristiq. If Effexor has pooped out on anyone, don't let anyone talk you out of trying Pristiq.
>

Jono is very knowledgeable about psychopharmacology as his comparison of Effexor/Pristiq to amitriptyline/nortriptyine demonstrates. However, yours is not the first story I have come across describing an advantage of Pristiq over Effexor. However, I must mention that you should not have abandoned Effexor until a dosage of 300 mg/day was tried. I believe that 100 mg of Pristiq might be therapeutically equivalent to over 200 mg of Effexor. I would have to study the pharmacokinetics of Effexor, but not all Effexor becomes Pristiq in the body. A certain percentage will be metabolized into inactive substances, so, one would need to take a higher dosage of Effexor to approximate the levels reached by Pristiq. Also, we don't know the degree to which the Effexor molecule might actually interfere with the actions of the Pristiq molecule.

Messy.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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