Posted by Trotter on December 28, 2012, at 13:50:52
In reply to Re: Bifidobacteria reduce depression » Trotter, posted by rca on December 28, 2012, at 8:55:02
> I think it is safe to assume that a meal high in saturated fat causes inflammation; that is a well-established fact accepted for at least 15 years. But the prevailing thought had been that saturated fat causes our gut lining to become leaky and allow our own bacteria (endotoxins) to slip into our blood stream and cause the inflammation. Then came the study cited below (Erridge, 201). We now know that the high load of bacteria in animal products contain endotoxins (even in dead bacteria so doesnt matter if cook at high temperatures or expose to highly acidic environments like the stomach). And animal fat may play a profound role in the pathogenesis of this after-meal inflammation by increasing the absorption of the endotoxins, since endotoxin has a strong affinity for the saturated fat transport system through the gut wall and into the blood stream (Deopurkar et al., 2010, below).
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> So what can you do? Whole food plant based diet.
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> Erridge C. The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4. Br J Nutr. 2011 Jan; 105(1):15-23.
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> Deopurkar R, Ghanim H, Friedman J, Abuaysheh S, Sia CL, Mohanty P, Viswanathan P, Chaudhuri A, Dandona P. Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care. 2010 May; 33(5):991-7.
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>You seem to assume that this laboratory study proves that endotoxemia is caused by endotoxins in protein or refined foods and not from the lumen via a permeable intestine. I agree it establishes that such foods contain some endotoxin, but that is all.
The bowel has massive amounts of endotoxin. I think the amount of endotoxin in the bowel regardless of whether one is on a plant or protein orientated diet dwarfs any endotoxin ingested in food. I still firmly believe a high fat diet causes endotoxemia due to increased intestinal permeability. I think this has been pretty well established in rodent studies which looked at high fat diets, not high protein diets.
poster:Trotter
thread:1033371
URL: http://www.dr-bob.org/babble/20121217/msgs/1034078.html