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Re: Parnate and Vitamin B1/Thiamine Deficiency???

Posted by neuroscience on November 6, 2012, at 7:50:48

In reply to Parnate and Vitamin B1/Thiamine Deficiency???, posted by adiaphora on November 6, 2012, at 3:10:19

> Does anyone have any experience and/or knowledge of Parnate/Tranylcypromine leading to thiamine (or other B vitamin, especially B12) deficiency? I have been on Tranylcypromine (60 mg/day) for about three months now and seem to be manifesting the symptoms of beriberi (pedal edema, lethargy, urinary incontinence, et al.; also I should probably admit that I have been living on a diet of processed carbohydrates through this last 6-month depressive episode). Some of the symptoms have subsided with over-the-counter thiamine and B-complex administration, but others (especially what I think would be accurately be called some version of peripheral neuropathy)are not improving very quickly if at all. I am considering going to an emergency room for diagnosis, but so far have met only opposition from the members of the medical community to whom I have access at the idea that a non-alcoholic person following a Standard American Diet could contract beriberi. I found some research that seems to point to a connection between thiamine deficiency and Tranylcypromine (Ali, B.H. (1985), Effect of some monoamine oxidase inhibitors on the thiamin status of rabbits. British Journal of Pharmacology, 86: 869875. doi: 10.1111/j.1476-5381.1985.tb11109.x; Wei, R., and L. M. Lewin. "The biosynthesis of thiamine: A yeast enzyme system which converts 2-methyl-4-amino-5-aminomethylpyridimine to 2-methyl-4-amino-5-hydroxymethylpyrimidine." Biochimica et Biophysica Acta (BBA)-General Subjects 230.2 (1971): 253-257.) but I am neither a biochemist nor a medical doctor (although of course even I understand that research on rats is not the same as work on humans), so I thought that I would appeal to the extensive knowledge and experience of so many on this board and see if what I am going through either rings any bells or makes any biochemical sense.
> p.s. I know that Nardil has been connected to B6 deficiency and I have read that research, but those symptoms just don't fit.

The symptoms might be caused by other things. I'm sure you thought of this already though. Did you get tested to see if something else is causing the urinary incontinence? I read that Tranylcypromine itself can cause urinary incontinence as a side-effect (and it can cause retarded ejaculation... oh man...).

When does the edema occur btw?


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