Posted by SLS on October 4, 2012, at 21:23:01
In reply to Re: PS. what should i do? » SLS, posted by phidippus on October 4, 2012, at 18:15:02
> >I hate to burst your bubble, but opinions do not go unchallenged here.
>
> My bubble is fine, so is my cherry.Good to know?
> >I thought that bipolar disorder was the issue we were dscussing.
> Why not include borderline personality in the discussion? Mood stabilizers are used to treat it as well.
And they work, too. Trileptal is the one that helps most. Zyprexa can be effective, too. In fact, the combination of the two can be an excellent treatment, especially when combined with DBT. I had the true privilege of being exposed to well over one hundred people who were treated for a variety of mental illnesses over an 8 year period while I was in a partial hospitalization program. This includes BPD. I remember one patient in particular who was refractory to behavioral therapies. Even with the unconditional support of her by the community, she remained very much affected. However, a new treatment regime was begun comprised of a combination of Trileptal and Zyprexa. Within a month her tantrums and crying spells disappeared, and she made excellent progress behaviorally. Unfortunately, she gained more weight than was healthy for her, and the Zyprexa was discontinued. I left the program not too long after this, so I don't know what became of her. However, until I left, she seemed stable on Trileptal monotherapy.
> http://www.psychiatrictimes.com/display/article/10168/46801
This is actually a very good article as it approaches the issue of what constitutes a "mood stabilizer". As I indicated in a previous post, there is quite a bit of debate as to how to define one.
"A consensus definition of mood stabilizer remains to be established, and international regulatory authorities do not officially recognize the term as a mode of drug activity.5 Clinicians and researchers apply the concept of mood stabilization to a range of compounds used in the treatment of bipolar disorder, although considerable variability can be found in the literature concerning the meaning and use of the term.6-11 In its broadest form, a mood stabilizer has been operationally described as an agent that is useful in at least 1 of the 3 phases of bipolar disorder (mania, bipolar depression, or long-term maintenance) while not increasing the frequency or severity of any of the other phases of the illness.6"
Zyprexa?
> > Your definition is fine, I just think its too bipolar specific.
> > You believe that lithium is acting as a mood stabilizer for you, despite your not having bipolar disorder.
> I am diagnosed Bipolar I with ADHD and OCD, did I say otherwise?
I apologize. So, you are not an example of mood stabilization in unipolar depression. Do you know anyone with unipolar MDD who has remitted as a result of lithium monotherapy? I don't, but that proves very little.
> > > My point is simply that Zyprexa is not a mood stabilizer. Its mechanism of action differentiates it from Lithium and all the anticonvulsants called mood stabilizers
> Let me modify my statement. No mood stabillizers are antipsychotics and no antipsychotics are mood stabilizers
Your surety is refreshing.
> > Must a drug have same properties as another in order treat the same illness effectively?
> In some ways, yes. Antipsychotics are all similar in the way they treat schizophrenia-I don't know of any that don't antagonize dopamine receptors.
How is this supportive of your assertion that any drug that acts as a mood stabilizer must have the pharmacology of lithium or of an anticovulsant exclusively? Are all drugs that treat tuberculosis MAO inhibitors? (Hint: No.)
> > I don't understand why you would have a problem with Zyprexa producing diabetes.
> I have a problem with Lilly's mishandling of reporting Zyprexa's serious side effects.
Me, too. So? The drug itself is not to blame for this. The drug is what it is. SSRIs were purported to be weight-neutral by the drug companies. Let's not use them anymore because the drug companies lied about this side effect. I guess the drugs stopped working as soon as they discovered their cover was blown.
> Honestly, I think our argument is moot when we look at Verapamil as a mood stabilizer. Verapamil is going to be huge!
Your enthusiasm for verapamil is interesting. I am having trouble detecting any sarcasm that might be present. In any event, this drug was looked at closely over 20 years ago. Success stories were sparse, and two clinical trials were negative. Then again, there has been no incentive to study this drug any further because it is off-patent.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1027311
URL: http://www.dr-bob.org/babble/20121001/msgs/1027669.html