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Re: MAOI + Inhibition + Antibiotic + HELP :( » gilmourr

Posted by SLS on September 22, 2012, at 8:40:26

In reply to MAOI + Inhibition + Antibiotic + HELP :(, posted by gilmourr on September 21, 2012, at 18:24:01

> This inhibited CYP 3A4 which most likely caused Nardil to become more concentrated in my body...

Where did you find the information regarding Nardil (phenelzine) and CYP3A4? I was under the impression that Nardil inhibited CYP3A4, but that it was not metabolized by it.

* Important: Nardil is metabolized primarily by monoamine oxidase. It actually inhibits its own metabolism. The higher the dosage of Nardil you take, the more rapidly it accumulates. In other words, going from 30 mg to 60 mg does not increase the amount of Nardil in the body by a factor of 2 only. The factor increases exponentially. Levels continue to increase for several weeks, even though one takes the same dosage. Some doctors believe that the dosage necessary to establish therapeutic MAO inhibition by Nardil is higher than the dosage necessary to maintain it. So, one might need to take 60 mg in order to initiate an antidepressant response, but only 45 mg to maintain it. Personally, I don't subscribe to this idea. Perhaps it happens in a minority of people. There always seems to be exceptions when it comes to psychopharmacology.

It has been my observation that most people with MDD need a minimum dosage of 60 mg/day of Nardil in order to respond optimally to it.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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