Posted by gilmourr on September 21, 2012, at 18:24:01
Here's a timeline of the events.
Was on Nardil 60 mg for 3-3.5 weeks, developed bad mood swings.
Stopped 60 mg on September 9th, went back to 45 mg. My mood swings have still been occuring until today.
Severe anxiety began on the 13th and lasted until the 18th
Started Biaxin (antibiotic) on the 15th until the 19th (5 days in total). This inhibited CYP 3A4 which most likely caused Nardil to become more concentrated in my body from the 15th - 19th (my body probably treated it like 60 mg)
My severe anxiety stopped on the 19th, no klonopin needed currently.
** Now my theory is that the 60 mg takes about 4 days to get out of my system. But then I started Biaxin which probably turned the new 45 mg level into 60 mg because Biaxin inhibits CYP3A4.
** One question is, if biaxin inhibits 3A4 and it concentrates to 60 mg, would the MAO regeneration period restart when I took the biaxin? And would MAO regeneration only start on the 19th because that's when I stopped it?
OPTION 1: I stay on 45 mg, nothing is inhibiting the Nardil now (I just take seroquel at night) and I hope that my mood picks up as the MAO regenerates.
OPTION 2: I use 30 mg for a few days to pick up the speed of MAO regeneration and then go back on 45 mg in like 5 days.
** Basically I'm throwing a big jam on the 28th and I don't want to have a severe mood swing, so I'm trying to get the mood swings down to a level I can handle by the 28th. If not, I'll just drink my depression away for that night I guess. :/
What would you do, option 1 or 2? And do you think I can just take klonopin if I feel depressed? Sometimes it gives me a high
EDIT: I took 30 mg in the day, I felt pretty level, then I took 15 mg more and now I'm having a mood swing. Though yesterday I took 45 mg altogether in the morning and didn't have a swing until 2 AM so I'm not sure if it matters what time I take the last 15..