Posted by linkadge on September 12, 2012, at 18:42:27
In reply to Re: is a GABA antagonist what i need? » AlexCanada, posted by phidippus on September 12, 2012, at 17:13:11
Dopamine can actually cause anhedonia too.
Dopamine release in the NAA can cause feelings of pleasure (acutely, in the short term). However when the NAA recieves prolonged exposure to dopamine, it can result in behavioral depression.
This is associated with an elevation of BDNF in the neucleus accumbens (bad) - and decrease of BDNF in the hippocampus.
Pleasure is meant to come only here and there (usually after the sucessful completion of a positive task). You don't want dopamine coming out of nowhere, for no reason, else you develop an addiction to the pleasure producing short cut, not the natural events in life that produce it.
People who use stimulants or opioids usually become antisocial. This is because the drug produces reward and the individual begins to focus more on the reward produced by the drug rather than natural social interaction (which can do the same thing).
The effect of dopamine on pleasure is inverse 'U' shaped. Why do you think that antipsychotics can reverse the severe behavioral withdrawl, apathy and other negative symptoms associated with schizophrenia?
Depression can be a side effects of ADD drugs like ritalin or dexedrine. According to my psychiatrist (who deals in ADD), its a fairly common side effect.