Posted by AlexCanada on September 6, 2012, at 15:11:05
In reply to Re: Increase dopamine for motivation without risks? » AlexCanada, posted by phidippus on September 5, 2012, at 14:54:31
With the information you've provided do any of the mechanisms of action have potential to effect someone negatively? especially someone with melancholic depression, poor cognition/drive/motivation/interest/pleasure/energy?
modafinil sometimes would make things look ''darker'' and my ability to enjoy things would not necessarily improve. possibly worse. Yet my motivation, energy, ability to think would benefit usually.
> Provigil and Nuvigil are both based on the drug Modafanil, so have similar modes of action.
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> Modafinil induces wakefulness in part by its action in the anterior hypothalamus. Its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent.
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> Modafinil has central alpha 1-adrenergic agonist effects i.e. it directly stimulates the receptors. Modafinil also inhibits the reuptake of noradrenaline by the noradrenergic terminals on sleep-promoting neurons of ventrolateral preoptic nucleus (VLPO). More significant, perhaps, is its ability to increase excitatory glutamatergic transmission. This reduces local GABAergic transmission, thereby diminishing GABA(A) receptor signalling on the mesolimbic dopamine terminals.
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> Orexin neurons are activated by modafinil. Orexinergic neurons are found exclusively in the lateral hypothalamic area. Their activation is associated with enhanced pleasure-seeking and motivation as well as arousal. Orexinergic fibers project to the entire central nervous system.
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> Eric
poster:AlexCanada
thread:1024774
URL: http://www.dr-bob.org/babble/20120830/msgs/1025004.html